Drug interactions
Apalutamide + Docetaxel
Severity: Moderate
Apalutamide and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce docetaxel exposure and potentially efficacy, though clinical data in prostate cancer indicate the combination has been used.
What this interaction means in plain words
Apalutamide and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Docetaxel belongs to Oncology.
Why it happens
CYP3A4 induction increases docetaxel metabolism.
What to do
Monitor treatment response and tolerability; no routine dose change is established, so reassess if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Apalutamide with Docetaxel?
MediHelp rates the interaction as moderate. Apalutamide and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce docetaxel exposure and potentially efficacy, though clinical data in prostate cancer indicate the combination has been used.
How serious is the interaction between Apalutamide and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and tolerability; no routine dose change is established, so reassess if efficacy appears reduced.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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