Drug interactions
Apalutamide + Glyburide-metformin
Severity: Moderate
Apalutamide and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C9 and other enzymes and transporters, which can lower glyburide exposure. This may reduce glycemic control and lead to hyperglycemia.
What this interaction means in plain words
Apalutamide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Glyburide-metformin belongs to Endocrine.
Why it happens
Induction of CYP2C9 (and possibly CYP3A4 and BCRP) increases glyburide metabolism and elimination.
What to do
Monitor blood glucose closely after starting apalutamide and increase the glyburide dose or change therapy if control worsens. Reassess if apalutamide is stopped, since glyburide exposure will rise again.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Glyburide-metformin?
MediHelp rates the interaction as moderate. Apalutamide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP2C9 and other enzymes and transporters, which can lower glyburide exposure. This may reduce glycemic control and lead to hyperglycemia.
How serious is the interaction between Apalutamide and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting apalutamide and increase the glyburide dose or change therapy if control worsens. Reassess if apalutamide is stopped, since glyburide exposure will rise again.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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