Drug interactions
Apalutamide + Hydrochlorothiazide-telmisartan
Severity: Minor
Apalutamide and Hydrochlorothiazide-telmisartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an enzyme inducer, and telmisartan is cleared by glucuronidation, so exposure to telmisartan may fall modestly. Reduced blood pressure control is possible but the effect is usually small.
What this interaction means in plain words
Apalutamide and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Apalutamide induction of UGT enzymes may increase telmisartan glucuronidation and clearance.
What to do
Monitor blood pressure after starting or stopping apalutamide. Adjust the antihypertensive dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as minor. Apalutamide and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is an enzyme inducer, and telmisartan is cleared by glucuronidation, so exposure to telmisartan may fall modestly. Reduced blood pressure control is possible but the effect is usually small.
How serious is the interaction between Apalutamide and Hydrochlorothiazide-telmisartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping apalutamide. Adjust the antihypertensive dose if control is lost.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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