Drug interactions
Apalutamide + Imipramine
Severity: Moderate
Apalutamide and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C19 and CYP3A4, which metabolize imipramine, and may lower imipramine concentrations. Antidepressant effect may be reduced.
What this interaction means in plain words
Apalutamide and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Enzyme induction of CYP2C19 and CYP3A4 by apalutamide increases imipramine clearance.
What to do
Monitor for loss of antidepressant response and consider imipramine dose increases guided by levels. Consider an alternative antidepressant if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Imipramine?
MediHelp rates the interaction as moderate. Apalutamide and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP2C19 and CYP3A4, which metabolize imipramine, and may lower imipramine concentrations. Antidepressant effect may be reduced.
How serious is the interaction between Apalutamide and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response and consider imipramine dose increases guided by levels. Consider an alternative antidepressant if response is lost.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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