Drug interactions
Apalutamide + Mitoxantrone
Severity: Minor
Apalutamide and Mitoxantrone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitoxantrone is a BCRP substrate, and apalutamide weakly induces BCRP. Mitoxantrone exposure may fall slightly, possibly reducing efficacy, but the effect is likely small.
What this interaction means in plain words
Apalutamide and Mitoxantrone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Mitoxantrone belongs to Central Nervous System.
Why it happens
Apalutamide induction of BCRP may increase mitoxantrone efflux and elimination.
What to do
No dose change routinely required; monitor treatment response and blood counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Mitoxantrone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mitoxantrone
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Mitoxantrone?
MediHelp rates the interaction as minor. Apalutamide and Mitoxantrone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mitoxantrone is a BCRP substrate, and apalutamide weakly induces BCRP. Mitoxantrone exposure may fall slightly, possibly reducing efficacy, but the effect is likely small.
How serious is the interaction between Apalutamide and Mitoxantrone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change routinely required; monitor treatment response and blood counts.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
