Drug interactions
Apalutamide + Pantoprazole
Severity: Minor
Apalutamide and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower pantoprazole exposure, possibly weakening acid suppression. The effect is usually modest in clinical terms, and the dose can be adjusted.
What this interaction means in plain words
Apalutamide and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Apalutamide induces CYP2C19 and CYP3A4, increasing pantoprazole metabolism.
What to do
Monitor for breakthrough reflux or ulcer symptoms and increase the pantoprazole dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Apalutamide with Pantoprazole?
MediHelp rates the interaction as minor. Apalutamide and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide may lower pantoprazole exposure, possibly weakening acid suppression. The effect is usually modest in clinical terms, and the dose can be adjusted.
How serious is the interaction between Apalutamide and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough reflux or ulcer symptoms and increase the pantoprazole dose if needed.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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