Drug interactions
Apalutamide + Raltegravir
Severity: Moderate
Apalutamide and Raltegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an inducer of UGT enzymes, and raltegravir is eliminated mainly by UGT1A1 glucuronidation. Raltegravir exposure may fall, risking reduced antiviral efficacy.
What this interaction means in plain words
Apalutamide and Raltegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Raltegravir belongs to Anti Virals.
Why it happens
Apalutamide induction of UGT1A1 increases raltegravir glucuronidation and clearance.
What to do
Monitor HIV viral load closely, and consider an alternative antiretroviral or antiandrogen if virological control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicated
- Aluminum hydroxide / magnesium carbonate + Raltegravir Major
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Major
- Aluminum hydroxide + Raltegravir Major
- Atidarsagene autotemcel + Raltegravir Major
- Betibeglogene autotemcel + Raltegravir Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Raltegravir?
MediHelp rates the interaction as moderate. Apalutamide and Raltegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is an inducer of UGT enzymes, and raltegravir is eliminated mainly by UGT1A1 glucuronidation. Raltegravir exposure may fall, risking reduced antiviral efficacy.
How serious is the interaction between Apalutamide and Raltegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load closely, and consider an alternative antiretroviral or antiandrogen if virological control is lost.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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