Drug interactions
Apalutamide + Salmeterol
Severity: Moderate
Apalutamide and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of CYP3A4 and may lower systemic exposure to salmeterol, which is cleared mainly by CYP3A4. Bronchodilator effect may be reduced, with poorer asthma or COPD control.
What this interaction means in plain words
Apalutamide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Salmeterol belongs to Respiratory.
Why it happens
Induction of hepatic and intestinal CYP3A4 by apalutamide increases salmeterol metabolism.
What to do
Monitor for reduced bronchodilator response and symptom control when starting or stopping apalutamide. Consider adjusting the maintenance regimen or adding a different class of bronchodilator if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Salmeterol?
MediHelp rates the interaction as moderate. Apalutamide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong inducer of CYP3A4 and may lower systemic exposure to salmeterol, which is cleared mainly by CYP3A4. Bronchodilator effect may be reduced, with poorer asthma or COPD control.
How serious is the interaction between Apalutamide and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bronchodilator response and symptom control when starting or stopping apalutamide. Consider adjusting the maintenance regimen or adding a different class of bronchodilator if control worsens.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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