Drug interactions
Apalutamide + Suvorexant
Severity: Moderate
Apalutamide and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce suvorexant concentrations and lessen its efficacy for insomnia. Suvorexant labeling advises against use with strong CYP3A inducers.
What this interaction means in plain words
Apalutamide and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Suvorexant belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4, increasing suvorexant metabolism.
What to do
Avoid the combination and use a hypnotic not dependent on CYP3A4. If used, monitor sleep efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Apalutamide with Suvorexant?
MediHelp rates the interaction as moderate. Apalutamide and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce suvorexant concentrations and lessen its efficacy for insomnia. Suvorexant labeling advises against use with strong CYP3A inducers.
How serious is the interaction between Apalutamide and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a hypnotic not dependent on CYP3A4. If used, monitor sleep efficacy.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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