Drug interactions
Apalutamide + Tamoxifen
Severity: Moderate
Apalutamide and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower tamoxifen exposure and alter formation of its active metabolite endoxifen. The overall effect on efficacy is uncertain, and the pair is rarely used together.
What this interaction means in plain words
Apalutamide and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Tamoxifen belongs to Endocrine.
Why it happens
CYP3A4 induction increases tamoxifen clearance.
What to do
Avoid the combination where possible and monitor for reduced tamoxifen efficacy. Consider an alternative endocrine agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Apalutamide with Tamoxifen?
MediHelp rates the interaction as moderate. Apalutamide and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may lower tamoxifen exposure and alter formation of its active metabolite endoxifen. The overall effect on efficacy is uncertain, and the pair is rarely used together.
How serious is the interaction between Apalutamide and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and monitor for reduced tamoxifen efficacy. Consider an alternative endocrine agent if needed.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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