Drug interactions
Apalutamide + Voxilaprevir
Severity: Contraindicated
Apalutamide and Voxilaprevir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide can markedly lower voxilaprevir levels, risking hepatitis C treatment failure.
What this interaction means in plain words
Apalutamide and Voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Voxilaprevir belongs to Anti Virals.
Why it happens
Apalutamide induces CYP3A4 and P-glycoprotein, increasing voxilaprevir clearance.
What to do
Do not co-administer with sofosbuvir/velpatasvir/voxilaprevir. Choose an alternative antiandrogen or delay HCV therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Voxilaprevir
- Phenytoin + Voxilaprevir Contraindicated
- Bosentan + Voxilaprevir Major
- Carbamazepine + Voxilaprevir Major
- Efavirenz + Voxilaprevir Major
- Enzalutamide + Voxilaprevir Major
- Lorlatinib + Voxilaprevir Major
Frequently asked questions
Can I take Apalutamide with Voxilaprevir?
MediHelp rates the interaction as contraindicated. Apalutamide and Voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide can markedly lower voxilaprevir levels, risking hepatitis C treatment failure.
How serious is the interaction between Apalutamide and Voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer with sofosbuvir/velpatasvir/voxilaprevir. Choose an alternative antiandrogen or delay HCV therapy.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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