Drug interactions
Enzalutamide + Voxilaprevir
Severity: Major
Enzalutamide and Voxilaprevir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxilaprevir is part of a fixed-dose hepatitis C regimen and is metabolized in part by CYP3A4. Enzalutamide may lower its exposure and risk reducing the chance of viral cure.
What this interaction means in plain words
Enzalutamide and Voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Voxilaprevir belongs to Anti Virals.
Why it happens
Enzalutamide induces CYP3A4 and drug transporters, reducing voxilaprevir concentrations.
What to do
Avoid concomitant use and choose an alternative antiandrogen or HCV regimen. Do not combine without specialist input.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Voxilaprevir
- Apalutamide + Voxilaprevir Contraindicated
- Phenytoin + Voxilaprevir Contraindicated
- Bosentan + Voxilaprevir Major
- Carbamazepine + Voxilaprevir Major
- Efavirenz + Voxilaprevir Major
- Lorlatinib + Voxilaprevir Major
Frequently asked questions
Can I take Enzalutamide with Voxilaprevir?
MediHelp rates the interaction as major. Enzalutamide and Voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voxilaprevir is part of a fixed-dose hepatitis C regimen and is metabolized in part by CYP3A4. Enzalutamide may lower its exposure and risk reducing the chance of viral cure.
How serious is the interaction between Enzalutamide and Voxilaprevir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an alternative antiandrogen or HCV regimen. Do not combine without specialist input.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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