Drug interactions
Apixaban + Dalteparin
Severity: Major
Apixaban and Dalteparin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using dalteparin with apixaban adds anticoagulant effect and increases the risk of major bleeding. Overlap is acceptable only briefly during transitions.
What this interaction means in plain words
Apixaban and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Additive anticoagulation through antithrombin-mediated and direct factor Xa inhibition.
What to do
Avoid simultaneous dosing; start apixaban when the next dalteparin dose would have been due. Monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Dalteparin?
MediHelp rates the interaction as major. Apixaban and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using dalteparin with apixaban adds anticoagulant effect and increases the risk of major bleeding. Overlap is acceptable only briefly during transitions.
How serious is the interaction between Apixaban and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid simultaneous dosing; start apixaban when the next dalteparin dose would have been due. Monitor for bleeding and hemoglobin.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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