Drug interactions
Apixaban + Iloperidone
Severity: Minor
Apixaban and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak CYP3A4 inhibitor and may slightly raise exposure to apixaban, which is partly metabolized by CYP3A4. The expected increase is small, but it could add to bleeding risk in vulnerable patients.
What this interaction means in plain words
Apixaban and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apixaban belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated apixaban metabolism by iloperidone.
What to do
No dose adjustment is usually required; monitor for bleeding, particularly in patients with renal impairment, advanced age or low body weight.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Apixaban with Iloperidone?
MediHelp rates the interaction as minor. Apixaban and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak CYP3A4 inhibitor and may slightly raise exposure to apixaban, which is partly metabolized by CYP3A4. The expected increase is small, but it could add to bleeding risk in vulnerable patients.
How serious is the interaction between Apixaban and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for bleeding, particularly in patients with renal impairment, advanced age or low body weight.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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