Drug interactions
Apomorphine + Asenapine
Severity: Moderate
Apomorphine and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may raise arrhythmia risk. They also have opposing dopaminergic actions, since asenapine blocks dopamine receptors that apomorphine stimulates.
What this interaction means in plain words
Apomorphine and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Asenapine belongs to Central Nervous System.
Why it happens
Additive QT effects, plus pharmacodynamic antagonism at dopamine receptors.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes. Monitor for reduced apomorphine efficacy and worsening motor symptoms in Parkinson's disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Asenapine?
MediHelp rates the interaction as moderate. Apomorphine and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may raise arrhythmia risk. They also have opposing dopaminergic actions, since asenapine blocks dopamine receptors that apomorphine stimulates.
How serious is the interaction between Apomorphine and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes. Monitor for reduced apomorphine efficacy and worsening motor symptoms in Parkinson's disease.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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