Drug interactions
Apomorphine + Azelastine
Severity: Moderate
Apomorphine and Azelastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause somnolence, dizziness and sudden sleep onset, and azelastine is a sedating antihistamine. Combined use may increase drowsiness and impair alertness.
What this interaction means in plain words
Apomorphine and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Azelastine belongs to Respiratory.
Why it happens
Additive central nervous system depression from dopaminergic somnolence and H1-antihistamine activity.
What to do
Counsel on somnolence and avoid driving if drowsy. Consider a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Azelastine?
MediHelp rates the interaction as moderate. Apomorphine and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause somnolence, dizziness and sudden sleep onset, and azelastine is a sedating antihistamine. Combined use may increase drowsiness and impair alertness.
How serious is the interaction between Apomorphine and Azelastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on somnolence and avoid driving if drowsy. Consider a non-sedating antihistamine if needed.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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