Drug interactions
Apomorphine + Cabergoline
Severity: Moderate
Apomorphine and Cabergoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are dopamine agonists, so combining them can add to dopaminergic effects such as nausea, orthostatic hypotension, somnolence, hallucinations and impulse control problems. This is often intentional in Parkinson disease but can increase adverse effects.
What this interaction means in plain words
Apomorphine and Cabergoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Cabergoline belongs to Endocrine.
Why it happens
Additive dopamine receptor agonism.
What to do
Titrate doses slowly and monitor blood pressure, sedation and psychiatric symptoms. Reduce one agent if dopaminergic adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
- Cabergoline + Promethazine Contraindicated
- Benperidol + Cabergoline Major
- Cabergoline + Chlorpromazine Major
- Cabergoline + Clarithromycin Major
- Cabergoline + Dexfenfluramine Major
- Cabergoline + Droperidol Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Cabergoline?
MediHelp rates the interaction as moderate. Apomorphine and Cabergoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are dopamine agonists, so combining them can add to dopaminergic effects such as nausea, orthostatic hypotension, somnolence, hallucinations and impulse control problems. This is often intentional in Parkinson disease but can increase adverse effects.
How serious is the interaction between Apomorphine and Cabergoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doses slowly and monitor blood pressure, sedation and psychiatric symptoms. Reduce one agent if dopaminergic adverse effects emerge.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Promethazine, Benperidol, Chlorpromazine. The full list is on the Cabergoline page.
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