Drug interactions
Apomorphine + Chloral hydrate
Severity: Moderate
Apomorphine and Chloral hydrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine commonly causes somnolence and sudden sleep onset, and chloral hydrate adds sedative effects. Combined use may increase drowsiness and the risk of falls or accidents.
What this interaction means in plain words
Apomorphine and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Chloral hydrate belongs to Central Nervous System.
Why it happens
Additive CNS depression from the sedative-hypnotic and the dopamine agonist.
What to do
Monitor for excessive daytime sedation and orthostatic effects, and reduce the sedative dose if needed. Counsel patients against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apomorphine and Chloral hydrate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Chloral hydrate?
MediHelp rates the interaction as moderate. Apomorphine and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine commonly causes somnolence and sudden sleep onset, and chloral hydrate adds sedative effects. Combined use may increase drowsiness and the risk of falls or accidents.
How serious is the interaction between Apomorphine and Chloral hydrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive daytime sedation and orthostatic effects, and reduce the sedative dose if needed. Counsel patients against driving or operating machinery.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
