Drug interactions
Apomorphine + Clonazepam
Severity: Moderate
Apomorphine and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness and sudden sleep episodes, and their combined use may intensify sedation and dizziness. Apomorphine can also cause orthostatic hypotension, adding to fall risk.
What this interaction means in plain words
Apomorphine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of GABA-A potentiation and dopaminergic sedation.
What to do
Monitor for excess sedation and orthostatic hypotension, particularly in older patients with Parkinson disease. Reduce the benzodiazepine dose if daytime somnolence develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Clonazepam?
MediHelp rates the interaction as moderate. Apomorphine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness and sudden sleep episodes, and their combined use may intensify sedation and dizziness. Apomorphine can also cause orthostatic hypotension, adding to fall risk.
How serious is the interaction between Apomorphine and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and orthostatic hypotension, particularly in older patients with Parkinson disease. Reduce the benzodiazepine dose if daytime somnolence develops.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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