Drug interactions
Apomorphine + Clozapine
Severity: Moderate
Apomorphine and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine blocks dopamine receptors and may counteract apomorphine's dopaminergic effect in Parkinson disease. Both drugs can also cause hypotension and sedation.
What this interaction means in plain words
Apomorphine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine receptors, with additive hypotensive effects.
What to do
Monitor motor control and blood pressure. Clozapine is a lower-risk antipsychotic in Parkinson disease, so the combination is manageable with monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Clozapine?
MediHelp rates the interaction as moderate. Apomorphine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine blocks dopamine receptors and may counteract apomorphine's dopaminergic effect in Parkinson disease. Both drugs can also cause hypotension and sedation.
How serious is the interaction between Apomorphine and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor control and blood pressure. Clozapine is a lower-risk antipsychotic in Parkinson disease, so the combination is manageable with monitoring.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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