Drug interactions
Apomorphine + Codeine
Severity: Moderate
Apomorphine and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause drowsiness, sudden sleep onset and hypotension, and codeine adds opioid sedation and respiratory depression. The combination may increase dizziness and falls.
What this interaction means in plain words
Apomorphine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Codeine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Monitor sedation and blood pressure, particularly on initiation or dose increases. Use the lowest effective codeine dose and counsel on fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Codeine?
MediHelp rates the interaction as moderate. Apomorphine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause drowsiness, sudden sleep onset and hypotension, and codeine adds opioid sedation and respiratory depression. The combination may increase dizziness and falls.
How serious is the interaction between Apomorphine and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, particularly on initiation or dose increases. Use the lowest effective codeine dose and counsel on fall risk.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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