Drug interactions
Apomorphine + Dimenhydrinate
Severity: Moderate
Apomorphine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness and dizziness, so combined use may increase sedation and impair alertness. Apomorphine may also cause orthostatic hypotension, which sedation can make more hazardous.
What this interaction means in plain words
Apomorphine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess sedation and postural dizziness, and counsel against driving until tolerance is established. Note that sedating antiemetics are generally preferred to avoid with apomorphine if an alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Apomorphine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness and dizziness, so combined use may increase sedation and impair alertness. Apomorphine may also cause orthostatic hypotension, which sedation can make more hazardous.
How serious is the interaction between Apomorphine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and postural dizziness, and counsel against driving until tolerance is established. Note that sedating antiemetics are generally preferred to avoid with apomorphine if an alternative exists.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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