Drug interactions
Apomorphine + Doxylamine
Severity: Moderate
Apomorphine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating first-generation antihistamine and apomorphine commonly causes somnolence and sudden sleep onset. Using them together can deepen drowsiness and impair alertness, coordination and driving ability.
What this interaction means in plain words
Apomorphine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Doxylamine belongs to Respiratory.
Why it happens
Additive central nervous system depression from histamine H1 blockade and dopaminergic effects of apomorphine.
What to do
Monitor for excessive sedation and counsel patients against driving or operating machinery. Reduce or stop doxylamine if daytime somnolence worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Doxylamine?
MediHelp rates the interaction as moderate. Apomorphine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating first-generation antihistamine and apomorphine commonly causes somnolence and sudden sleep onset. Using them together can deepen drowsiness and impair alertness, coordination and driving ability.
How serious is the interaction between Apomorphine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients against driving or operating machinery. Reduce or stop doxylamine if daytime somnolence worsens.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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