Drug interactions
Apomorphine + Ezogabine
Severity: Moderate
Apomorphine and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and apomorphine has also been linked to QT prolongation. Combined use may add to the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Apomorphine and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Ezogabine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check a baseline ECG and monitor the QT interval, and correct electrolyte disturbances. Avoid the combination in patients with congenital long QT syndrome or other major risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Ezogabine?
MediHelp rates the interaction as moderate. Apomorphine and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation, and apomorphine has also been linked to QT prolongation. Combined use may add to the risk of arrhythmia in susceptible patients.
How serious is the interaction between Apomorphine and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor the QT interval, and correct electrolyte disturbances. Avoid the combination in patients with congenital long QT syndrome or other major risk factors.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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