Drug interactions
Apomorphine + Lorazepam
Severity: Moderate
Apomorphine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine commonly causes somnolence and sudden sleep onset, and lorazepam can add to this. Hypotension and dizziness may also be more pronounced.
What this interaction means in plain words
Apomorphine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant and sedative pharmacodynamic effects.
What to do
Monitor for excessive sleepiness and orthostatic hypotension and advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Lorazepam?
MediHelp rates the interaction as moderate. Apomorphine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine commonly causes somnolence and sudden sleep onset, and lorazepam can add to this. Hypotension and dizziness may also be more pronounced.
How serious is the interaction between Apomorphine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sleepiness and orthostatic hypotension and advise against driving until the response is known.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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