Drug interactions
Apomorphine + Ofloxacin
Severity: Moderate
Apomorphine and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so their combined use may raise the risk of torsades de pointes and other serious ventricular arrhythmias. The risk is greater with electrolyte disturbances, bradycardia or existing heart disease.
What this interaction means in plain words
Apomorphine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation through blockade of cardiac potassium channels (hERG).
What to do
Prefer an antibiotic with less QT effect when feasible. If combined, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Ofloxacin?
MediHelp rates the interaction as moderate. Apomorphine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so their combined use may raise the risk of torsades de pointes and other serious ventricular arrhythmias. The risk is greater with electrolyte disturbances, bradycardia or existing heart disease.
How serious is the interaction between Apomorphine and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic with less QT effect when feasible. If combined, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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