Drug interactions
Apomorphine + Oxazepam
Severity: Moderate
Apomorphine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause somnolence, sudden sleep onset and orthostatic hypotension, which may add to the sedative effect of oxazepam. The combination may increase drowsiness and fall risk.
What this interaction means in plain words
Apomorphine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects (pharmacodynamic).
What to do
Monitor for excessive sedation and orthostatic hypotension, and reduce the oxazepam dose if drowsiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Oxazepam?
MediHelp rates the interaction as moderate. Apomorphine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause somnolence, sudden sleep onset and orthostatic hypotension, which may add to the sedative effect of oxazepam. The combination may increase drowsiness and fall risk.
How serious is the interaction between Apomorphine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostatic hypotension, and reduce the oxazepam dose if drowsiness develops.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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