Drug interactions
Apomorphine + Ropinirole
Severity: Moderate
Apomorphine and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dopamine agonists, so combined use adds dopaminergic effects. This may increase nausea, hypotension, somnolence, dyskinesia and hallucinations, though the combination is used in advanced Parkinson disease.
What this interaction means in plain words
Apomorphine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Ropinirole belongs to Central Nervous System.
Why it happens
Additive stimulation of dopamine receptors.
What to do
Monitor orthostatic blood pressure, sedation and psychiatric symptoms, and reduce the oral agonist dose if adverse effects arise. Titrate changes gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Ropinirole?
MediHelp rates the interaction as moderate. Apomorphine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dopamine agonists, so combined use adds dopaminergic effects. This may increase nausea, hypotension, somnolence, dyskinesia and hallucinations, though the combination is used in advanced Parkinson disease.
How serious is the interaction between Apomorphine and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure, sedation and psychiatric symptoms, and reduce the oral agonist dose if adverse effects arise. Titrate changes gradually.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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