Drug interactions
Apomorphine + Salbutamol
Severity: Moderate
Apomorphine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salbutamol (particularly at high or nebulised doses, via hypokalemia and tachycardia) and apomorphine can prolong the QT interval. Combined use may increase the risk of ventricular arrhythmias, especially in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Apomorphine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia further increasing arrhythmia susceptibility.
What to do
Check potassium and magnesium and correct deficits; consider ECG monitoring in patients with cardiac risk factors or when high-dose salbutamol is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Salbutamol?
MediHelp rates the interaction as moderate. Apomorphine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salbutamol (particularly at high or nebulised doses, via hypokalemia and tachycardia) and apomorphine can prolong the QT interval. Combined use may increase the risk of ventricular arrhythmias, especially in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Apomorphine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits; consider ECG monitoring in patients with cardiac risk factors or when high-dose salbutamol is needed.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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