Drug interactions
Apremilast + Eslicarbazepine
Severity: Moderate
Apremilast and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apremilast is metabolized by CYP3A4, and strong inducers substantially reduce exposure and may cause loss of efficacy. Eslicarbazepine is a weaker inducer, so a smaller reduction is expected.
What this interaction means in plain words
Apremilast and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apremilast belongs to Miscellaneous; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine induces CYP3A4, increasing apremilast metabolism.
What to do
Monitor clinical response of the psoriasis or arthritis and consider an alternative anticonvulsant if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apremilast and Eslicarbazepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Apremilast
- Apalutamide + Apremilast Major
- Apremilast + Carbamazepine Major
- Apremilast + Efavirenz Major
- Apremilast + Enzalutamide Major
- Apremilast + Phenytoin Major
- Apremilast + Rifampicin Major
Frequently asked questions
Can I take Apremilast with Eslicarbazepine?
MediHelp rates the interaction as moderate. Apremilast and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apremilast is metabolized by CYP3A4, and strong inducers substantially reduce exposure and may cause loss of efficacy. Eslicarbazepine is a weaker inducer, so a smaller reduction is expected.
How serious is the interaction between Apremilast and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response of the psoriasis or arthritis and consider an alternative anticonvulsant if efficacy is lost.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
