Drug interactions
Apremilast + Ribociclib
Severity: Minor
Apremilast and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy direction (ribociclib decreasing apremilast) is inconsistent with CYP3A4 inhibition, which would not reduce apremilast levels. Apremilast is cleared by several pathways, so any change from ribociclib is likely small and not clinically meaningful.
What this interaction means in plain words
Apremilast and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apremilast belongs to Miscellaneous; Ribociclib belongs to Oncology.
Why it happens
Ribociclib CYP3A4 inhibition would be expected to slightly raise, not lower, apremilast exposure, and apremilast has multiple clearance routes.
What to do
No dose change is needed. Monitor for gastrointestinal effects and mood changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Apremilast
- Apalutamide + Apremilast Major
- Apremilast + Carbamazepine Major
- Apremilast + Efavirenz Major
- Apremilast + Enzalutamide Major
- Apremilast + Phenytoin Major
- Apremilast + Rifampicin Major
Frequently asked questions
Can I take Apremilast with Ribociclib?
MediHelp rates the interaction as minor. Apremilast and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy direction (ribociclib decreasing apremilast) is inconsistent with CYP3A4 inhibition, which would not reduce apremilast levels. Apremilast is cleared by several pathways, so any change from ribociclib is likely small and not clinically meaningful.
How serious is the interaction between Apremilast and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for gastrointestinal effects and mood changes.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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