Drug interactions
Aprepitant + Axitinib
Severity: Moderate
Aprepitant and Axitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise axitinib exposure. This may increase axitinib toxicities such as hypertension, diarrhea and hepatotoxicity.
What this interaction means in plain words
Aprepitant and Axitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Axitinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated axitinib metabolism by aprepitant.
What to do
Monitor blood pressure and tolerability closely and reduce the axitinib dose if adverse effects emerge. A short aprepitant course may be acceptable with monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Axitinib?
MediHelp rates the interaction as moderate. Aprepitant and Axitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise axitinib exposure. This may increase axitinib toxicities such as hypertension, diarrhea and hepatotoxicity.
How serious is the interaction between Aprepitant and Axitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability closely and reduce the axitinib dose if adverse effects emerge. A short aprepitant course may be acceptable with monitoring.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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