Drug interactions
Aprepitant + Belzutifan
Severity: Moderate
Aprepitant and Belzutifan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower concentrations of sensitive CYP3A4 substrates such as aprepitant. Reduced aprepitant exposure could weaken antiemetic protection.
What this interaction means in plain words
Aprepitant and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Belzutifan belongs to Miscellaneous.
Why it happens
Belzutifan induction of CYP3A4 increases aprepitant metabolism.
What to do
Monitor for breakthrough nausea and vomiting, and add or optimize other antiemetics if control is inadequate. Avoid the combination if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Aprepitant with Belzutifan?
MediHelp rates the interaction as moderate. Aprepitant and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower concentrations of sensitive CYP3A4 substrates such as aprepitant. Reduced aprepitant exposure could weaken antiemetic protection.
How serious is the interaction between Aprepitant and Belzutifan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting, and add or optimize other antiemetics if control is inadequate. Avoid the combination if possible.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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