Drug interactions
Aprepitant + Cevimeline
Severity: Minor
Aprepitant and Cevimeline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is metabolized by CYP3A4 and CYP2D6, and aprepitant may raise its levels. Cholinergic effects such as sweating, nausea and bradycardia could be amplified.
What this interaction means in plain words
Aprepitant and Cevimeline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Cevimeline belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 by aprepitant decreases cevimeline metabolism.
What to do
No routine dose change is needed. Watch for cholinergic adverse effects during aprepitant courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Aprepitant with Cevimeline?
MediHelp rates the interaction as minor. Aprepitant and Cevimeline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cevimeline is metabolized by CYP3A4 and CYP2D6, and aprepitant may raise its levels. Cholinergic effects such as sweating, nausea and bradycardia could be amplified.
How serious is the interaction between Aprepitant and Cevimeline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for cholinergic adverse effects during aprepitant courses.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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