Drug interactions
Aprepitant + Cyclophosphamide
Severity: Minor
Aprepitant and Cyclophosphamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide is activated partly by CYP3A4 and CYP2B6, and aprepitant may alter this activation. Clinical studies have not shown a meaningful change in cyclophosphamide exposure or efficacy with aprepitant.
What this interaction means in plain words
Aprepitant and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Cyclophosphamide belongs to Oncology.
Why it happens
Aprepitant's CYP3A4 inhibition could theoretically alter cyclophosphamide bioactivation, but the effect appears small.
What to do
No dose adjustment is required; monitor for usual cyclophosphamide toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Aprepitant with Cyclophosphamide?
MediHelp rates the interaction as minor. Aprepitant and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclophosphamide is activated partly by CYP3A4 and CYP2B6, and aprepitant may alter this activation. Clinical studies have not shown a meaningful change in cyclophosphamide exposure or efficacy with aprepitant.
How serious is the interaction between Aprepitant and Cyclophosphamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for usual cyclophosphamide toxicity.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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