Drug interactions
Aprepitant + Docetaxel
Severity: Moderate
Aprepitant and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel is cleared mainly by CYP3A4, and aprepitant could increase its exposure. In clinical studies, aprepitant did not produce a meaningful change in docetaxel pharmacokinetics.
What this interaction means in plain words
Aprepitant and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Docetaxel belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, which could reduce docetaxel clearance.
What to do
No empiric dose change is needed; monitor for neutropenia and other docetaxel toxicities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Docetaxel
Frequently asked questions
Can I take Aprepitant with Docetaxel?
MediHelp rates the interaction as moderate. Aprepitant and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Docetaxel is cleared mainly by CYP3A4, and aprepitant could increase its exposure. In clinical studies, aprepitant did not produce a meaningful change in docetaxel pharmacokinetics.
How serious is the interaction between Aprepitant and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor for neutropenia and other docetaxel toxicities.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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