Drug interactions
Aprepitant + Drospirenone
Severity: Moderate
Aprepitant and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may reduce the effectiveness of hormonal contraceptives, including those containing drospirenone, probably through induction of metabolism over several days. Drospirenone is not a significant CYP3A4 inhibitor affecting aprepitant.
What this interaction means in plain words
Aprepitant and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Drospirenone belongs to Endocrine.
Why it happens
Aprepitant induces CYP3A4 (and other enzymes), which may lower contraceptive steroid concentrations.
What to do
Advise an additional non-hormonal contraceptive method during aprepitant treatment and for about one month afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Aprepitant with Drospirenone?
MediHelp rates the interaction as moderate. Aprepitant and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant may reduce the effectiveness of hormonal contraceptives, including those containing drospirenone, probably through induction of metabolism over several days. Drospirenone is not a significant CYP3A4 inhibitor affecting aprepitant.
How serious is the interaction between Aprepitant and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during aprepitant treatment and for about one month afterwards.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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