Drug interactions
Aprepitant + Erlotinib
Severity: Moderate
Aprepitant and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erlotinib is metabolized mainly by CYP3A4, so aprepitant may raise its concentrations. This can increase rash, diarrhea and other dose-related adverse effects.
What this interaction means in plain words
Aprepitant and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Erlotinib belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing erlotinib clearance.
What to do
Monitor for erlotinib toxicity such as severe diarrhea and rash, and reduce the dose stepwise if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Aprepitant with Erlotinib?
MediHelp rates the interaction as moderate. Aprepitant and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erlotinib is metabolized mainly by CYP3A4, so aprepitant may raise its concentrations. This can increase rash, diarrhea and other dose-related adverse effects.
How serious is the interaction between Aprepitant and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity such as severe diarrhea and rash, and reduce the dose stepwise if it occurs.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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