Drug interactions
Aprepitant + Fesoterodine
Severity: Minor
Aprepitant and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fesoterodine is converted to its active metabolite 5-hydroxymethyl tolterodine, which is cleared by CYP3A4 and CYP2D6. Aprepitant may increase its exposure and anticholinergic adverse effects.
What this interaction means in plain words
Aprepitant and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Fesoterodine belongs to Genitourinary.
Why it happens
Aprepitant inhibits CYP3A4, reducing clearance of the active metabolite.
What to do
Monitor for anticholinergic effects such as dry mouth, constipation and urinary retention; adjust the dose if bothersome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aprepitant and Fesoterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Fesoterodine
Frequently asked questions
Can I take Aprepitant with Fesoterodine?
MediHelp rates the interaction as minor. Aprepitant and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fesoterodine is converted to its active metabolite 5-hydroxymethyl tolterodine, which is cleared by CYP3A4 and CYP2D6. Aprepitant may increase its exposure and anticholinergic adverse effects.
How serious is the interaction between Aprepitant and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, constipation and urinary retention; adjust the dose if bothersome.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
