Drug interactions
Aprepitant + Ibrutinib
Severity: Moderate
Aprepitant and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise ibrutinib exposure. This may increase ibrutinib toxicities such as bleeding, arrhythmias and cytopenias.
What this interaction means in plain words
Aprepitant and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Ibrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated ibrutinib metabolism by aprepitant.
What to do
Reduce the ibrutinib dose in line with labeling for moderate CYP3A4 inhibitors and monitor for toxicity, including bleeding and atrial arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Aprepitant with Ibrutinib?
MediHelp rates the interaction as moderate. Aprepitant and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise ibrutinib exposure. This may increase ibrutinib toxicities such as bleeding, arrhythmias and cytopenias.
How serious is the interaction between Aprepitant and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ibrutinib dose in line with labeling for moderate CYP3A4 inhibitors and monitor for toxicity, including bleeding and atrial arrhythmias.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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