Drug interactions
Aprepitant + Ifosfamide
Severity: Moderate
Aprepitant and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is activated and also converted to neurotoxic metabolites by CYP3A4. Aprepitant's effect on CYP3A4 could alter this balance, but clinical studies have not shown a consistent effect on ifosfamide pharmacokinetics or neurotoxicity.
What this interaction means in plain words
Aprepitant and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Ifosfamide belongs to Oncology.
Why it happens
Aprepitant may modulate CYP3A4-dependent ifosfamide activation and neurotoxic metabolite formation, but the effect is uncertain.
What to do
Monitor for ifosfamide neurotoxicity such as confusion, somnolence and hallucinations during therapy. Stop or adjust ifosfamide per protocol if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Aprepitant with Ifosfamide?
MediHelp rates the interaction as moderate. Aprepitant and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is activated and also converted to neurotoxic metabolites by CYP3A4. Aprepitant's effect on CYP3A4 could alter this balance, but clinical studies have not shown a consistent effect on ifosfamide pharmacokinetics or neurotoxicity.
How serious is the interaction between Aprepitant and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ifosfamide neurotoxicity such as confusion, somnolence and hallucinations during therapy. Stop or adjust ifosfamide per protocol if symptoms occur.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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