Drug interactions
Aprepitant + Istradefylline
Severity: Minor
Aprepitant and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg/day inhibits CYP3A4 and may raise aprepitant concentrations. At 20 mg/day this effect was not seen.
What this interaction means in plain words
Aprepitant and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline weakly inhibits CYP3A4 at higher doses, reducing aprepitant clearance.
What to do
Monitor aprepitant tolerability if istradefylline 40 mg/day is used. Use of the 20 mg dose avoids the issue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Aprepitant with Istradefylline?
MediHelp rates the interaction as minor. Aprepitant and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg/day inhibits CYP3A4 and may raise aprepitant concentrations. At 20 mg/day this effect was not seen.
How serious is the interaction between Aprepitant and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aprepitant tolerability if istradefylline 40 mg/day is used. Use of the 20 mg dose avoids the issue.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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