Drug interactions
Aprepitant + Ivosidenib
Severity: Moderate
Aprepitant and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower aprepitant concentrations. This may reduce antiemetic protection against chemotherapy-induced nausea and vomiting.
What this interaction means in plain words
Aprepitant and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing aprepitant clearance.
What to do
Monitor for breakthrough nausea and vomiting and add or switch antiemetics if control is inadequate. Ivosidenib exposure may rise with aprepitant, so monitor for QTc prolongation and differentiation syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Aprepitant with Ivosidenib?
MediHelp rates the interaction as moderate. Aprepitant and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower aprepitant concentrations. This may reduce antiemetic protection against chemotherapy-induced nausea and vomiting.
How serious is the interaction between Aprepitant and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add or switch antiemetics if control is inadequate. Ivosidenib exposure may rise with aprepitant, so monitor for QTc prolongation and differentiation syndrome.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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