Drug interactions
Aprepitant + Lefamulin
Severity: Moderate
Aprepitant and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a CYP3A4 and P-gp substrate and moderate inhibitors may raise its exposure. Increased concentrations may add to QT prolongation, which lefamulin and some antiemetic regimens can also cause.
What this interaction means in plain words
Aprepitant and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Lefamulin belongs to Anti Bacterial.
Why it happens
Aprepitant inhibits CYP3A4, reducing lefamulin metabolism.
What to do
Monitor for adverse effects including QT prolongation and GI effects. Check ECG if other QT-prolonging drugs are given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Aprepitant with Lefamulin?
MediHelp rates the interaction as moderate. Aprepitant and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin is a CYP3A4 and P-gp substrate and moderate inhibitors may raise its exposure. Increased concentrations may add to QT prolongation, which lefamulin and some antiemetic regimens can also cause.
How serious is the interaction between Aprepitant and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects including QT prolongation and GI effects. Check ECG if other QT-prolonging drugs are given.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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