Drug interactions
Aprepitant + Lorlatinib
Severity: Moderate
Aprepitant and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower aprepitant concentrations, potentially reducing antiemetic protection. Aprepitant, a CYP3A4 substrate, may also modestly affect lorlatinib. Lorlatinib labeling warns against combining it with sensitive CYP3A substrates.
What this interaction means in plain words
Aprepitant and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing aprepitant clearance.
What to do
Monitor for breakthrough nausea and vomiting and add other antiemetics if needed; consider a non-CYP3A4-dependent antiemetic strategy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Aprepitant with Lorlatinib?
MediHelp rates the interaction as moderate. Aprepitant and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower aprepitant concentrations, potentially reducing antiemetic protection. Aprepitant, a CYP3A4 substrate, may also modestly affect lorlatinib. Lorlatinib labeling warns against combining it with sensitive CYP3A substrates.
How serious is the interaction between Aprepitant and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add other antiemetics if needed; consider a non-CYP3A4-dependent antiemetic strategy.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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