Drug interactions
Aprepitant + Lumateperone
Severity: Moderate
Aprepitant and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may increase lumateperone exposure by inhibiting CYP3A4. This may increase sedation, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Aprepitant and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Lumateperone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated lumateperone metabolism by aprepitant.
What to do
Reduce lumateperone to 21 mg daily during coadministration with a moderate CYP3A4 inhibitor. Monitor for sedation and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Lumateperone
Frequently asked questions
Can I take Aprepitant with Lumateperone?
MediHelp rates the interaction as moderate. Aprepitant and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant may increase lumateperone exposure by inhibiting CYP3A4. This may increase sedation, orthostatic hypotension and other adverse effects.
How serious is the interaction between Aprepitant and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 21 mg daily during coadministration with a moderate CYP3A4 inhibitor. Monitor for sedation and hypotension.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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