Drug interactions
Aprepitant + Mavacamten
Severity: Major
Aprepitant and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared by CYP2C19 and CYP3A4, and aprepitant inhibits CYP3A4. Higher exposure can excessively reduce ejection fraction and cause heart failure.
What this interaction means in plain words
Aprepitant and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Mavacamten belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated mavacamten metabolism by aprepitant.
What to do
Monitor left ventricular ejection fraction and clinical status closely, and adjust the mavacamten dose per labeling. Reassess when aprepitant is started or stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Aprepitant with Mavacamten?
MediHelp rates the interaction as major. Aprepitant and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten is cleared by CYP2C19 and CYP3A4, and aprepitant inhibits CYP3A4. Higher exposure can excessively reduce ejection fraction and cause heart failure.
How serious is the interaction between Aprepitant and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical status closely, and adjust the mavacamten dose per labeling. Reassess when aprepitant is started or stopped.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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