Drug interactions
Aprepitant + Methadone
Severity: Moderate
Aprepitant and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone is metabolized by CYP3A4 and CYP2B6, so aprepitant may raise its levels. Studies suggest the effect on methadone is small, but excessive sedation, respiratory depression or QT prolongation are possible.
What this interaction means in plain words
Aprepitant and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Methadone belongs to Musculoskeletal.
Why it happens
Aprepitant inhibits CYP3A4 metabolism of methadone, though it also induces CYP2C9 and perhaps CYP2B6.
What to do
Monitor for sedation, respiratory depression and withdrawal or opioid toxicity; check ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Aprepitant with Methadone?
MediHelp rates the interaction as moderate. Aprepitant and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone is metabolized by CYP3A4 and CYP2B6, so aprepitant may raise its levels. Studies suggest the effect on methadone is small, but excessive sedation, respiratory depression or QT prolongation are possible.
How serious is the interaction between Aprepitant and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and withdrawal or opioid toxicity; check ECG in patients with QT risk factors.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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