Drug interactions
Aprepitant + Nifedipine
Severity: Moderate
Aprepitant and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a CYP3A4 substrate and aprepitant, a moderate inhibitor, may raise its levels. Hypotension, flushing, peripheral edema and tachycardia may be more pronounced. Nifedipine has little effect as a CYP3A4 inhibitor on aprepitant.
What this interaction means in plain words
Aprepitant and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Nifedipine belongs to Cardiovascular.
Why it happens
Aprepitant inhibits CYP3A4-mediated metabolism of nifedipine.
What to do
Monitor blood pressure and heart rate during and after aprepitant dosing and reduce the nifedipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Aprepitant with Nifedipine?
MediHelp rates the interaction as moderate. Aprepitant and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nifedipine is a CYP3A4 substrate and aprepitant, a moderate inhibitor, may raise its levels. Hypotension, flushing, peripheral edema and tachycardia may be more pronounced. Nifedipine has little effect as a CYP3A4 inhibitor on aprepitant.
How serious is the interaction between Aprepitant and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during and after aprepitant dosing and reduce the nifedipine dose if hypotension occurs.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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