Drug interactions
Aprepitant + Nilotinib
Severity: Major
Aprepitant and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is mainly cleared by CYP3A4 and prolongs the QT interval. Aprepitant may raise nilotinib levels and increase the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Aprepitant and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Nilotinib belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4 metabolism of nilotinib, with additive QT risk.
What to do
Obtain baseline and follow-up ECGs and correct potassium and magnesium; consider an alternative antiemetic or nilotinib dose reduction if QT lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Aprepitant with Nilotinib?
MediHelp rates the interaction as major. Aprepitant and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib is mainly cleared by CYP3A4 and prolongs the QT interval. Aprepitant may raise nilotinib levels and increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Aprepitant and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECGs and correct potassium and magnesium; consider an alternative antiemetic or nilotinib dose reduction if QT lengthens.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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